Flcn autophagy
Tīmeklis2010. gada 30. nov. · Binding partner of the GTPase-activating protein FLCN: involved in the cellular response to amino acid availability by regulating the mTORC1 ... Together with FLCN, regulates autophagy: following phosphorylation by ULK1, interacts with GABARAP and promotes autophagy (PubMed:25126726). In addition to its role in … Tīmeklis2024. gada 12. aug. · Autophagy is a fundamental cellular process that eliminates molecules and subcellular elements, including nucleic acids, proteins, lipids and organelles, via lysosome-mediated degradation to...
Flcn autophagy
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TīmeklisIn low-amino acid conditions, the lysosomal folliculin complex (LFC) is formed on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, … Tīmeklis2024. gada 15. nov. · The folliculin (FLCN) tumor suppressor complex (FLCN, FNIP1, FNIP2) is implicated in the regulation of energy homeostasis via 2 …
Tīmeklis2024. gada 1. maijs · Autophagy is an evolutionarily conserved intracellular homoeostatic process wherein cytoplasmic cargo-containing autophagosomes fuse with lysosomes to degrade the cargo 1. TīmeklisThe causative gene, FLCN, is a tumor suppressor, which encodes folliculin (FLCN), a 64 kDa protein ( 22 ). Although little was known about FLCN function until recently, current studies have shown that FLCN may orchestrate a number of intracellular signaling pathways ( 23, 24 ).
TīmeklisFLcN is a positive driver of autophagy. (A) hK2 control and FLCN knockdown cells were transfected with the ptfMaP1Lc3B vector, fixed, and examined by confocal microscopy. Representative maximal Z-projection images of cells showing the RFP-GFP-MaP1Lc3B puncta are shown in the FLCN FLCN TīmeklisFolliculin (FLCN) is a tumor-suppressor protein mutated in the Birt–Hogg–Dubé (BHD) syndrome, which associates with two paralogous proteins, folliculin-interacting protein (FNIP)1 and FNIP2, forming a complex that interacts with the AMP-activated protein kinase (AMPK).
The tumor suppressor gene FLCN encodes the protein folliculin, also known as Birt–Hogg–Dubé syndrome protein, which functions as an inhibitor of Lactate Dehydrogenase-A and a regulator of the Warburg effect. Folliculin (FLCN) is also associated with Birt–Hogg–Dubé syndrome, which is an … Skatīt vairāk Structure The FLCN gene consists of 14 exons. Location Cytogenetic location: The FLCN gene is located on the short (p) arm of chromosome 17 … Skatīt vairāk Interactions FLCN has been shown to interact through its C-terminus with two new co-chaperones folliculin … Skatīt vairāk • FLCN+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • The BHD Foundation Archived 2024-06-11 at the Wayback Machine supports … Skatīt vairāk • Schmidt LS, Linehan WM (October 2015). "Molecular genetics and clinical features of Birt-Hogg-Dubé syndrome". Nature Reviews. … Skatīt vairāk
Tīmeklis2024. gada 10. febr. · Autophagy is a process that degrades and recycles superfluous organelles or damaged cellular contents. It has been found to have dual functions in renal cell carcinoma (RCC). Many autophagy-related proteins are regarded as prognostic markers of RCC. is it good to buy ford stockTīmeklis2024. gada 11. sept. · Autophagy is primarily regulated by the transcription factors TFEB and TFE3, which are negatively regulated by mTORC1. Given that FLCN is an … kerry perry picturesTīmeklis2024. gada 24. marts · Autophagy was initially described as an adaptive process to starvation, promoting energy maintenance; the recycling of senescent or disabled macromolecules and organelles; and providing the building blocks for de novo synthesis of macromolecules. Autophagy is highly conserved among eukaryotes. kerry perry fireworksTīmeklis2015. gada 16. marts · Germline alteration of the folliculin ( FLCN) gene, a novel tumor suppressor, is responsible for Birt–Hogg–Dubé (BHD) syndrome, an inherited kidney … is it good to buy home nowTīmeklis2024. gada 14. sept. · The tumor suppressor folliculin (FLCN) is a RagC/D guanosine triphosphatase (GTPase)–activating protein (GAP) that regulates mTORC1 phosphorylation of MiT-TFE transcription factors, controlling lysosome biogenesis and … kerry pharmaceuticalTīmeklis2024. gada 18. marts · FLCN is the gene associated with the Birt-Hogg-Dubé neoplastic syndrome in humans, characterized by predisposition to renal cell carcinoma, skin … is it good to buy lic ipoTīmeklisAutophagy: the basics Macroautophagy (hereafter referred as autophagy) is an evolutionarily conserved process used by cells to sequester intracellular components inside double-membrane organelles, called autophagosomes. These organelles fuse with lysosomes to degrade their content and recycle nutrients back to the cytoplasm ( … is it good to buy hfcl shares