Cisplatin dna cross-linking

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WebDec 22, 2024 · Cisplatin has been widely used for the treatment of cancer and its antitumour activity is attributed to its capacity to form DNA adducts, predominantly at guanine residues, which impede cellular processes … WebWe evaluated the growth and molecular interactions of the anti-EGFR antibody cetuximab (erbitux) and the DNA cross-linking agent cisplatin (cis-diammedichloroplatinum; CDDP) in the gefitinib-resistant MDA-MB-468 breast cancer cell line, an in vitro model system that shows many of the recurrent basal-like molecular abnormalities including …

Molecules Free Full-Text The Challenging Treatment of Cisplatin ...

WebRecent studies have shown that the majority of proteins cross-linked to DNA by cisplatin in situ are nuclear matrix proteins ( 2 - 4 ). We have also shown that cisplatin cross-links … WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different diseases. Recently, it has been demonstrated that ABs from human renal proximal tubular HK-2 cells, either induced by cisplatin or by UV light, can lead to further apoptotic death in … churchill downs trackside training center

Evidence for different mechanisms of ‘unhooking’ for melphalan …

WebSep 28, 2012 · DNA cross-linking agents such as the nitrogen mustards (melphalan, chlorambucil, cyclophosphamide, ifosfamide), platinum drugs (cisplatin, carboplatin, oxaliplatin), chloroethylnitrosoureas (carmustine, lomustine), the alkylalkane sulphonate busulphan and the natural product mitomycin C are widely used drugs as both single … WebJan 1, 2001 · We compared the DNA cross-linking capability of CC-1065 with that of its analogs: Bizelesin, which forms DNA cross-links by direct chemical bonding, and Adozelesin, a demethoxy derivative of CC-1065. Section snippets Drugs WebThis chapter deals with the interstrand cross-links in cisplatin- or transplatin-modified DNA and focuses on three main aspects: the formation of the interstrand cross-links, the distortions induced in the DNA double helix and the potential use of the interstrand cross-linking reaction in the context of antisense and antigene strategies. churchill downs turfway park

Differential expression of collateral sensitivity or resistance to ...

The interactions of novel mononuclear platinum-based …

WebApr 17, 2024 · The antitumor effects of cisplatin and other platinum compounds are attributed to their ability to induce interstrand DNA-DNA cross-links, which are thought … WebJun 20, 2024 · It has long been established that the mechanism of cis- DDP involves DNA intrastrand cross-link formation ( 6, 7 ), altering the molecular conformation of the double helix leading to apoptosis. churchill downs track mapWebThe DNA binding is similar to cisplatin, and the complex forms a highly stereoselective adduct on DNA, but not for reactions with mono- and dinucleotides. 98 In cell lines with previously determined mechanisms of cell resistance, AMD473 showed little cross-resistance compared with cisplatin or carboplatin. churchill downs tours museum

"WebCisplatin crosslinks DNA in several different ways, interfering with cell division by mitosis. The damaged DNA elicits DNA repair mechanisms, which in turn activate apoptosis … " - Cisplatin dna cross-linking

Cisplatin dna cross-linking

Cisplatin - an overview ScienceDirect Topics

WebTumour cells isolated from 50 ovarian cancer patients were treated ex vivo with 100 μ M cisplatin for 1 h and crosslink formation and repair (unhooking) measured. ... in cellular mechanisms such as drug transport or detoxification. In contrast, the percentage repair (unhooking) of DNA interstrand crosslinks was much greater in the group of ... WebJul 23, 1996 · Abstract cis-Diamminedichloroplatinum (II) (cisplatin) is a widely used anticancer drug that binds to and crosslinks DNA. The major DNA adduct of the drug results from coordination of two adjacent guanine bases to platinum to form the intrastrand crosslink cis- [Pt (NH3)2 [d (GpG)-N7 (1), -N7 (2)]] (cis-Pt-GG).

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WebNov 15, 1987 · Two sublines were derived from a human bladder carcinoma continuous cell line (RT112-P), one by exposure to fractionated X-irradiation (RT112-DXR8) and the other by continuous exposure to cisplatin (RT112-CP). RT112-DXR8 cells were 1.6- to 2-fold more sensitive to cisplatin and 2 analogues, carbopla … WebFeb 21, 2000 · Most simple cis-PtA2G2 complexes that model the G-G cross-link DNA lesions caused by the clinically used anticancer drug cis-PtCl2 (NH3)2 undergo large fluxional motions at a rapid rate (A2 = two amines or a diamine; G = guanine derivative).

WebCisplatin Medicine & Life Sciences 74%. DNA Repair Medicine & Life Sciences 50%. DNA Medicine & Life Sciences 46%. DNA Adducts Medicine & Life Sciences 34%. ... (II) and Modification of Platinum-induced DNA Interstrand Cross-Linking. / Swinnen, Lode J.; Barnes, Diane M.; Fisher, Susan G. et al. WebThe platinum 1,3-d(GXG) intrastrand cross-link is one of the adducts formed in the reaction of the antitumor drug cisplatin with DNA, and in fact the major adduct found in cells treated with the cisplatin analogue carboplatin. ... cross-link and other Pt-DNA cross-links sheds new light on the observed differences in protein recognition of these ...

WebDNA crosslinking agents, such as cisplatin derivatives (carboplatin and oxaliplatin) and mitomycin C, are especially cytotoxic to tumor cells, and their therapeutic index derives, … WebA Phase III, Randomized, Open-Label, Multi-Center, Global Study to Determine the Efficacy and Safety of Durvalumab in Combination With Gemcitabine+Cisplatin for Neoadjuvant Treatment Followed by Durvalumab Alone for Adjuvant Treatment in Patients With Muscle-Invasive Bladder Cancer

WebCisplatin produces DNA cross-linking and is used to treat medulloblastoma, head and neck, ovarian, germ cell, cervical, lung and bladder cancers. Cisplatin produces a … churchill downs turf club seating chartWebFeb 1, 2002 · To overcome this obstacle, researchers have focussed their attention on cisplatin (cis-DDP; cis-platinum (II)diamminedichloride), a cross-linking agent shown to … churchill downs tours ticketsWebPhoto-cross-linking is thus an effective tool for investigating the interaction of cisplatin-modified DNA with damage-recognition proteins under heterogeneous conditions such those in cell extracts or living cells. † Supported by Grant … churchill downs transportationWebDNA interstrand crosslinks (ICLs) formed by antitumor agents, such as cisplatin or mitomycin C, are highly cytotoxic DNA lesions. Their repair is believed to be triggered primarily by the stalling of replication forks at ICLs in S-phase. There is, however, increasing evidence that ICL repair can also occur independently of replication. devin ratray weightWebOct 26, 1995 · Solution structure of a cisplatin-induced DNA interstrand cross-link. The widely used antitumor drug cis-diamminedichloroplatinum (II) (cisplatin or cis-DDP) … churchill downs tours packagesWebFeb 28, 2024 · Indeed, while cisplatin probably undergoes an efflux effect, compound 19 shows a time-dependent accumulation in cells and a greater ability to cross the membrane. DNA interaction has been confirmed for both complexes due to the presence of the triphenylphosphine hydrophobic moiety and the trans geometry of bromide groups. churchill downs turf club seatingWebCisplatin induces DNA damage through inter-strand or intra-strand cross-linking of DNA . Its dose-limiting toxicity is nephrotoxicity, peripheral nerve toxicity, and toxicity to the cochlea (the inner ear toxicity) . Paclitaxel is a microtubule poison that … churchill downs tour tickets